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KMID : 1145520190050020135
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Journal of Radiopharmaceuticals and Molecular Probes
2019 Volume.5 No. 2 p.135 ~ p.144
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Targeted alpha therapy (TAT) for cancer using metallic radioisotopes
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Kang Chi-Soo
Lee Kyo-Chul
Lee Yong-Jin
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Abstract
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Targeted alpha therapy (TAT) based on metallic radionuclides has attracted a lot of attention lately due toits impressive therapeutic efficacy displayed in couple of clinical studies for cancer. Representative metallicradionuclides emitting alpha-particle include 225Ac, 213Bi, and 227Th, and there have been variety of TATformulations based on different targeting moiety and chelating agents. In this review, we introduce strategiesto label metallic radioisotopes with biomolecules and look at some of recent preclinical and clinical results ofTAT for cancer.
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KEYWORD
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Targeted alpha therapy (TAT), metal chelators, Ac-225, Bi-213, Th-227
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